Established functional tests and validated experimental setups for biodistribution measurements allow fast implementation of orientating studies.
Drug delivery using the Soluventis platform technology. A typical particle size is 50 nm, other sizes depending on target organ and active substance are possible. The active substances are completely covered avoiding contact to blood and immune system. The specific receptor-mediated endosomal uptake is independent of the transported active substance. Due to distinct surface compounds solving the endosomal membrane, all particles leave the endosomes within 5 to 15 minutes. The active substances are only released when particle is degraded in the cytoplasm, 2 - 4 hours following injection.